N
Function
Encapsidates the viral RNA genome by forming a left-handed helical nucleocapsid that protects the RNA from nucleases (PubMed:19965480, PubMed:23677789, PubMed:31229488). RNA replication depends on the availability of soluble nucleoprotein (PubMed:22623798, PubMed:9299631). The encapsidated genomic RNA is termed the NC and serves as template for transcription and replication (PubMed:22623798). Together with the phosphoprotein, sequesters host NF-kappa-B in inclusion bodies (IBs) thereby inhibiting this host defense pathway (PubMed:32878896). May also act as a modulator of the innate immune response by sequestration of host IFIH1/MDA5 and MAVS into IBs (PubMed:22623778).
Post-translational modifications
Tyrosine phosphorylation modulates viral transcription and replication.
Sequence Similarities
Belongs to the paramyxoviruses nucleocapsid family.
Cellular localization
- Virion
- Host cytoplasm
- Localizes in cytoplasmic inclusion bodies.
Alternative names
Nucleoprotein, Protein N, Nucleocapsid protein, N