MFGE8
Domain
The F5/8 type C 2 domain mediates high-affinity binding to phosphatidylserine-containing membranes.
Function
Plays an important role in the maintenance of intestinal epithelial homeostasis and the promotion of mucosal healing. Promotes VEGF-dependent neovascularization (By similarity). Contributes to phagocytic removal of apoptotic cells in many tissues. Specific ligand for the alpha-v/beta-3 and alpha-v/beta-5 receptors. Also binds to phosphatidylserine-enriched cell surfaces in a receptor-independent manner. Zona pellucida-binding protein which may play a role in gamete interaction.
Medin
Main constituent of aortic medial amyloid.
Post-translational modifications
Medin has a ragged N-terminus with minor species starting at Pro-264 and Gly-273.
Tissue Specificity
Mammary epithelial cell surfaces and aortic media. Overexpressed in several carcinomas.
Cellular localization
- Membrane
- Peripheral membrane protein
- Secreted
- Cytoplasmic vesicle
- Secretory vesicle
- Acrosome membrane
- Peripheral membrane protein
- Located in the acrosomal region of zona-pellucida bound sperm.
Alternative names
Lactadherin, Breast epithelial antigen BA46, HMFG, MFGM, Milk fat globule-EGF factor 8, SED1, MFG-E8, MFGE8