MACIR
Function
Regulates the macrophage function, by enhancing the resolution of inflammation and wound repair functions mediated by M2 macrophages (PubMed:30659109). The regulation of macrophage function is, due at least in part, to its ability to inhibit glycolysis (PubMed:30659109). May also play a role in trafficking of proteins via its interaction with UNC119 and UNC119B cargo adapters: may help the release of UNC119 and UNC119B cargo or the recycling of UNC119 and UNC119B (PubMed:22085962). May play a role in ciliary membrane localization via its interaction with UNC119B and protein transport into photoreceptor cells (PubMed:22085962).
Post-translational modifications
Phosphorylated.
Sequence Similarities
Belongs to the UNC119-binding protein family.
Tissue Specificity
High expression in normal macrophages, monocytes, and cultured rheumatoid arthritis synovial fibroblasts (RASFs), with lower expression in B- and T-cells, and little to no expression in other tissues and cell lines.
Cellular localization
- Cytoplasm
- Cell projection
- Cilium
- Localizes to the transition zone and proximal cilium in addition to being found throughout the cytoplasm.
Alternative names
C5orf30, MACIR, Macrophage immunometabolism regulator