LSR
Function
Probable role in the clearance of triglyceride-rich lipoprotein from blood. Binds chylomicrons, LDL and VLDL in presence of free fatty acids and allows their subsequent uptake in the cells (By similarity). Maintains epithelial barrier function by recruiting MARVELD2/tricellulin to tricellular tight junctions (By similarity).
Involvement in disease
Defects in LSR may be the cause of familial intrahepatic cholestasis.
Post-translational modifications
Phosphorylation at Ser-365 by MAPK8/JNK1 and MAPK9/JNK2 may be required for exclusive localization at tricellular tight junstions.
Sequence Similarities
Belongs to the immunoglobulin superfamily. LISCH7 family.
Cellular localization
- Cell membrane
- Single-pass type I membrane protein
- Cell junction
- Tight junction
- Located at tricellular contacts.
Alternative names
ILDR3, LISCH, LSR, Lipolysis-stimulated lipoprotein receptor, Angulin-1