LGALS1
GeneName
LGALS1
Summary
LGALS1, also known as Galectin-1 or Gal-1, is a 15 kDa protein that plays a multifaceted role in various biological processes. It is expressed in multiple tissues and is found in both the cytoplasm and extracellular space, including the extracellular matrix and exosomes. LGALS1 is involved in cell-cell adhesion and has been implicated in apoptosis regulation, myoblast differentiation, and T cell costimulation. Its functions are mediated through its ability to bind to lactose, laminin, and RNA, and it participates in the positive regulation of inflammatory responses and NF-kappaB signalling pathways.
Importance
LGALS1 is relevant to: - Immune modulation, particularly in T cell responses and the regulation of T-helper 17 cell lineage commitment - Cancer biology, as it influences cell adhesion and apoptosis, potentially affecting tumour progression and metastasis - Inflammatory diseases, due to its role in the positive regulation of inflammatory responses - Viral infections, as it enhances viral entry into host cells, making it a target for therapeutic interventions.
Top Products
For researchers investigating LGALS1, we recommend two excellent primary antibodies that cater to various applications. The first is the well-cited polyclonal antibody, Anti-Galectin 1 antibody (ab25138), which has garnered 39 citations, reflecting its reliability in the field. This antibody is suitable for Western blotting (WB), immunohistochemistry (IHC), and immunocytochemistry (ICC), making it a versatile choice for your research needs. Additionally, we offer the recombinant antibody, Anti-Galectin 1 antibody [EPR3205] (ab108389). This monoclonal antibody has been validated for the same applications—WB, IHC, and ICC—and has 16 citations, indicating its growing acceptance among researchers. The recombinant nature of this product ensures batch-to-batch consistency, providing confidence in your experimental results. Both antibodies are excellent options for studying LGALS1 effectively. The Human Galectin 1 Matched Antibody Pair Kit (ab218170) is an excellent option for researchers looking to study LGALS1 with precision.
Abcam Product Citation Summary
The data indicates that LGALS1 is primarily studied in human hepatic stellate cells and liver samples, particularly in the context of hepatocellular carcinoma and galectin-1 expression. The use of both western blotting and immunohistochemistry suggests a focus on protein detection and localisation in these studies.
Abcam Product Citation Table
Function
Lectin that binds beta-galactoside and a wide array of complex carbohydrates. Plays a role in regulating apoptosis, cell proliferation and cell differentiation. Inhibits CD45 protein phosphatase activity and therefore the dephosphorylation of Lyn kinase. Strong inducer of T-cell apoptosis. Plays a negative role in Th17 cell differentiation via activation of the receptor CD69 (PubMed:24752896).
Tissue Specificity
Expressed in placenta, maternal decidua and fetal membranes. Within placenta, expressed in trophoblasts, stromal cells, villous endothelium, syncytiotrophoblast apical membrane and villous stroma. Within fetal membranes, expressed in amnion, chorioamniotic mesenchyma and chorion (at protein level). Expressed in cardiac, smooth, and skeletal muscle, neurons, thymus, kidney and hematopoietic cells.
Cellular localization
- Secreted
- Extracellular space
- Extracellular matrix
- Cytoplasm
- Secreted
- Can be secreted; the secretion is dependent on protein unfolding and facilitated by the cargo receptor TMED10; it results in protein translocation from the cytoplasm into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) followed by vesicle entry and secretion.
Alternative names
Galectin-1, Gal-1, 14 kDa laminin-binding protein, 14 kDa lectin, Beta-galactoside-binding lectin L-14-I, Galaptin, HBL, HPL, Lactose-binding lectin 1, Lectin galactoside-binding soluble 1, Putative MAPK-activating protein PM12, S-Lac lectin 1, HLBP14, LGALS1