KIF1C
Function
Motor required for the retrograde transport of Golgi vesicles to the endoplasmic reticulum. Has a microtubule plus end-directed motility.
Involvement in disease
Spastic ataxia 2, autosomal recessive
SPAX2
A neurologic disorder characterized by cerebellar ataxia, dysarthria, and variable spasticity of the lower limbs. Cognition is not affected.
None
The disease is caused by variants affecting the gene represented in this entry.
Post-translational modifications
Phosphorylated on tyrosine residues.
Sequence Similarities
Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. Unc-104 subfamily.
Tissue Specificity
Expressed in all tissues examined, with most abundant expression in heart and skeletal muscle.
Cellular localization
- Cytoplasm
- Cytoskeleton
Alternative names
KIAA0706, KIF1C, Kinesin-like protein KIF1C