Jmjd1c
Domain
Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs are known to mediate the association with nuclear receptors.
Function
Probable histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate. May be involved in hormone-dependent transcriptional activation, by participating in recruitment to androgen-receptor target genes (By similarity).
Sequence Similarities
Belongs to the JHDM2 histone demethylase family.
Cellular localization
- Nucleus
Alternative names
Jhdm2c, Kiaa1380, Vglut3, Slc17a8, Probable JmjC domain-containing histone demethylation protein 2C, Jumonji domain-containing protein 1C