JMJD1C

Domain

Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs are known to mediate the association with nuclear receptors.

Function

Probable histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate. May be involved in hormone-dependent transcriptional activation, by participating in recruitment to androgen-receptor target genes (By similarity).

Sequence Similarities

Belongs to the JHDM2 histone demethylase family.

Cellular localization

• Nucleus

Alternative names

JHDM2C, KIAA1380, TRIP8, JMJD1C, Probable JmjC domain-containing histone demethylation protein 2C, Jumonji domain-containing protein 1C, Thyroid receptor-interacting protein 8, TR-interacting protein 8, TRIP-8

Database links

swissprot:Q15652 entrezGene:221037 omim:604503 ncbi:NP_004232.2