ITGAX

Domain

The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage.

Function

Integrin alpha-X/beta-2 is a receptor for fibrinogen. It recognizes the sequence G-P-R in fibrinogen. It mediates cell-cell interaction during inflammatory responses. It is especially important in monocyte adhesion and chemotaxis.

Sequence Similarities

Belongs to the integrin alpha chain family.

Tissue Specificity

Predominantly expressed in monocytes and granulocytes.

Cellular localization

• Membrane
• Single-pass type I membrane protein

Alternative names

CD11c, CD11C, ITGAX, Integrin alpha-X, CD11 antigen-like family member C, Leu M5

Database links

swissprot:P20702 omim:151510 entrezGene:3687

Other research areas

• Immuno-oncology