ITGA2

Domain

The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage.

Function

Integrin alpha-2/beta-1 is a receptor for laminin, collagen, collagen C-propeptides, fibronectin and E-cadherin. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. It is responsible for adhesion of platelets and other cells to collagens, modulation of collagen and collagenase gene expression, force generation and organization of newly synthesized extracellular matrix.

(Microbial infection) Integrin ITGA2:ITGB1 acts as a receptor for Human rotavirus A.

(Microbial infection) Integrin ITGA2:ITGB1 acts as a receptor for Human echoviruses 1 and 8.

Sequence Similarities

Belongs to the integrin alpha chain family.

Cellular localization

• Membrane
• Single-pass type I membrane protein

Alternative names

CD49b, CD49B, ITGA2, Integrin alpha-2, CD49 antigen-like family member B, Collagen receptor, Platelet membrane glycoprotein Ia, VLA-2 subunit alpha, GPIa

Database links

swissprot:P17301 omim:135630 omim:192974 swissprot:P05556 entrezGene:3673 entrezGene:3688

Other research areas

• Immuno-oncology