IL1RN
Function
Anti-inflammatory antagonist of interleukin-1 family of proinflammatory cytokines such as interleukin-1beta/IL1B and interleukin-1alpha/IL1A. Protects from immune dysregulation and uncontrolled systemic inflammation triggered by IL1 for a range of innate stimulatory agents such as pathogens.
Involvement in disease
Microvascular complications of diabetes 4
MVCD4
Pathological conditions that develop in numerous tissues and organs as a consequence of diabetes mellitus. They include diabetic retinopathy, diabetic nephropathy leading to end-stage renal disease, and diabetic neuropathy. Diabetic retinopathy remains the major cause of new-onset blindness among diabetic adults. It is characterized by vascular permeability and increased tissue ischemia and angiogenesis.
None
Disease susceptibility is associated with variants affecting the gene represented in this entry.
Chronic recurrent multifocal osteomyelitis 2, with periostitis and pustulosis
CRMO2
An autosomal recessive, autoinflammatory disease of skin and bone resulting in sterile multifocal osteomyelitis, periostitis, and pustulosis from birth. The term autoinflammatory disease describes a group of disorders characterized by attacks of seemingly unprovoked inflammation without significant levels of autoantibodies and autoreactive T-cells.
None
The disease is caused by variants affecting the gene represented in this entry.
Sequence Similarities
Belongs to the IL-1 family.
Tissue Specificity
The intracellular form of IL1RN is predominantly expressed in epithelial cells.
Cellular localization
- Isoform 1
- Secreted
- Isoform 2
- Cytoplasm
- Isoform 3
- Cytoplasm
- Isoform 4
- Cytoplasm
Alternative names
IL1F3, IL1RA, IL1RN, Interleukin-1 receptor antagonist protein, IL-1RN, IL-1ra, IRAP, ICIL-1RA, IL1 inhibitor