IL1RL2
Domain
The TIR domain mediates NAD(+) hydrolase (NADase) activity. Self-association of TIR domains is required for NADase activity.
Function
Receptor for interleukin-36 (IL36A, IL36B and IL36G). After binding to interleukin-36 associates with the coreceptor IL1RAP to form the interleukin-36 receptor complex which mediates interleukin-36-dependent activation of NF-kappa-B, MAPK and other pathways (By similarity). The IL-36 signaling system is thought to be present in epithelial barriers and to take part in local inflammatory response; it is similar to the IL-1 system. Seems to be involved in skin inflammatory response by induction of the IL-23/IL-17/IL-22 pathway.
Sequence Similarities
Belongs to the interleukin-1 receptor family.
Tissue Specificity
Expressed in synovial fibroblasts and articular chondrocytes. Expressed in keratinocytes and monocyte-derived dendritic cells. Expressed in monocytes and myeloid dendritic cells; at protein level.
Cellular localization
- Membrane
- Single-pass type I membrane protein
Alternative names
IL1RRP2, IL1RL2, Interleukin-1 receptor-like 2, IL-36 receptor, Interleukin-1 receptor-related protein 2, IL-36R, IL-1Rrp2, IL1R-rp2