gH
Function
The heterodimer glycoprotein H-glycoprotein L is required for the fusion of viral and plasma membranes leading to virus entry into the host cell. Following initial binding to host receptor, membrane fusion is mediated by the fusion machinery composed of gB and the heterodimer gH/gL. May also be involved in the fusion between the virion envelope and the outer nuclear membrane during virion morphogenesis.
Post-translational modifications
N-glycosylated, O-glycosylated, and sialylated.
Sequence Similarities
Belongs to the herpesviridae glycoprotein H family.
Cellular localization
- Virion membrane
- Single-pass type I membrane protein
- Host cell membrane
- Single-pass type I membrane protein
- Host endosome membrane
- Single-pass type I membrane protein
- During virion morphogenesis, this protein probably accumulates in the endosomes and trans-Golgi where secondary envelopment occurs. It is probably transported to the cell surface from where it is endocytosed and directed to the trans-Golgi network (TGN).
Alternative names
UL22, gH, Envelope glycoprotein H