GAK
Function
Associates with cyclin G and CDK5. Seems to act as an auxilin homolog that is involved in the uncoating of clathrin-coated vesicles by Hsc70 in non-neuronal cells. Expression oscillates slightly during the cell cycle, peaking at G1 (PubMed:10625686). May play a role in clathrin-mediated endocytosis and intracellular trafficking, and in the dynamics of clathrin assembly/disassembly (PubMed:18489706).
Sequence Similarities
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
Tissue Specificity
Ubiquitous. Highest in testis.
Cellular localization
- Cytoplasm
- Perinuclear region
- Golgi apparatus
- trans-Golgi network
- Cell junction
- Focal adhesion
- Cytoplasmic vesicle
- Clathrin-coated vesicle
- Localizes to the perinuclear area and to the trans-Golgi network. Also seen on the plasma membrane, probably at focal adhesions. Recruitment to clathrin-coated vesicles depends on temporal variations in phosphoinositide composition of clathrin-coated vesicles (PubMed:31962345).
Alternative names
DNAJC26, GAK, Cyclin-G-associated kinase, DnaJ homolog subfamily C member 26