G
Function
Attaches the virus to host cellular receptor, inducing clathrin-dependent endocytosis of the virion. In the endosome, the acidic pH induces conformational changes in the glycoprotein trimer, which trigger fusion between virus and endosomal membrane. In neurons, neo-synthesized glycoproteins are sorted to the dendrites, where the virus buds.
Post-translational modifications
Glycosylated by host. Palmitoylated by host on Cys-489 (By similarity).
Sequence Similarities
Belongs to the vesiculovirus glycoprotein family.
Cellular localization
- Virion membrane
- Single-pass type I membrane protein
- Host membrane
- Single-pass type I membrane protein
- The cytoplasmic domain sorts the protein to neurons dentrites instead of axons. When expressed in ex vivo polarized cells like epithelial cells, it sorts the protein to the basolateral side (By similarity).
Alternative names
Glycoprotein, G