FGD2
Domain
The FYVE-type zinc-finger is necessary for early endosome localization. Recruitment to endosomal membranes via this domain requires the presence of phosphatidylinositol 3-phosphate or other phosphatidylinositides (By similarity).
The PH domain is necessary for localization to the ruffle membrane. Recruitment to ruffle membrane occurs through binding of phosphoinositides by the PH domain. This domain also contributes to the lipid-binding properties of the protein (By similarity).
The DH domain is necessary for its ability to activate JNK1 via CDC42.
Function
Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Activates JNK1 via CDC42 but not RAC1. Binds to phosphatidylinositol 4,5-bisphosphate, phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 5-monophosphate, phosphatidylinositol 4-monophosphate and phosphatidylinositol 3-monophosphate (By similarity).
Cellular localization
- Cytoplasm
- Cytoskeleton
- Cytoplasm
- Nucleus
- Early endosome
- Early endosome membrane
- Cell projection
- Ruffle membrane
- Recruitment to the endosome and ruffle membrane requires the presence of phosphoinositides.
Alternative names
ZFYVE4, FGD2, Zinc finger FYVE domain-containing protein 4