FCGR1A

Function

High affinity receptor for the Fc region of immunoglobulins gamma. Functions in both innate and adaptive immune responses. Mediates IgG effector functions on monocytes triggering antibody-dependent cellular cytotoxicity (ADCC) of virus-infected cells.

Post-translational modifications

Phosphorylated on serine residues.

Sequence Similarities

Belongs to the immunoglobulin superfamily. FCGR1 family.

Tissue Specificity

Monocyte/macrophage specific.

Cellular localization

• Cell membrane
• Single-pass type I membrane protein
• Stabilized at the cell membrane through interaction with FCER1G.

Alternative names

CD64, FCG1, FCGR1, IGFR1, FCGR1A, High affinity immunoglobulin gamma Fc receptor I, IgG Fc receptor I, Fc-gamma RI, Fc-gamma RIA, FcRI, FcgammaRIa

Database links

swissprot:P12314 entrezGene:2210 entrezGene:2209 omim:146760 omim:601502 omim:601503 swissprot:Q92637 swissprot:A6NKC4