FAM168A
Function
In cancer context, protects cells from induced-DNA damage and apoptosis. Acts, at least in part, through PI3K/AKT/NFKB signaling pathway and by preventing POLB degradation. Decreases POLB ubiquitation and stabilizes its protein levels.
Involvement in disease
Associated with cisplatin (DDP)-resistance and radioresistance in the treatment of lung cancer as well as oral squamous cell carcinoma and poor clinical outcome in patients.
Sequence Similarities
Belongs to the FAM168 family.
Alternative names
KIAA0280, TCRP1, FAM168A, Protein FAM168A, Tongue cancer chemotherapy resistance-associated protein 1