Eif2b5 phospho S539
Function
Acts as a component of the translation initiation factor 2B (eIF2B) complex, which catalyzes the exchange of GDP for GTP on eukaryotic initiation factor 2 (eIF2) gamma subunit. Its guanine nucleotide exchange factor activity is repressed when bound to eIF2 complex phosphorylated on the alpha subunit, thereby limiting the amount of methionyl-initiator methionine tRNA available to the ribosome and consequently global translation is repressed.
Post-translational modifications
Phosphorylated on serine and threonine residues by GSK3B; phosphorylation inhibits its function (By similarity). Phosphorylated at Ser-539 by DYRK2; this is required for subsequent phosphorylation by GSK3B.
Polyubiquitinated, probably by NEDD4.
Sequence Similarities
Belongs to the eIF-2B gamma/epsilon subunits family.
Cellular localization
- Cytoplasm
- Cytosol
Alternative names
Eif2be, Eif2b5, Translation initiation factor eIF2B subunit epsilon, eIF2B GDP-GTP exchange factor subunit epsilon