DUSP13B

Function

Dual specificity phosphatase that dephosphorylates MAPK8/JNK and MAPK14/p38, but not MAPK1/ERK2, in vitro (PubMed:21360282). Exhibits intrinsic phosphatase activity towards both phospho-seryl/threonyl and -tyrosyl residues, with similar specific activities in vitro (PubMed:10585869).

Sequence Similarities

Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.

Tissue Specificity

Highly expressed in the testis (at protein level) (PubMed:10585869, PubMed:15252030). Also found in the skeletal muscle (PubMed:15252030).

Alternative names

DUSP13, SKRP4, TMDP, DUSP13B, Dual specificity protein phosphatase 13B, Dual specificity phosphatase SKRP4, Testis- and skeletal-muscle-specific DSP

Database links

swissprot:Q9UII6 swissprot:Q6B8I1 entrezGene:51207 omim:613191