DPYSL3
Function
Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, neuronal growth cone collapse and cell migration (By similarity).
Post-translational modifications
Phosphorylation on Ser-522 by DYRK2 promotes subsequent phosphorylation on Thr-509, Thr-514 and Ser-518 by GSK3.
Sequence Similarities
Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family.
Tissue Specificity
Mainly expressed in heart and skeletal muscle. Also strongly expressed in fetal brain and spinal cord.
Cellular localization
- Cytoplasm
- Cell projection
- Growth cone
- Colocalizes with synaptic vesicle protein 2 in the central region of the growth cone.
Alternative names
CRMP4, DRP3, ULIP, ULIP1, DPYSL3, Dihydropyrimidinase-related protein 3, DRP-3, Collapsin response mediator protein 4, Unc-33-like phosphoprotein 1, CRMP-4, ULIP-1