CYBRD1
Function
Plasma membrane reductase that uses cytoplasmic ascorbate as an electron donor to reduce extracellular Fe(3+) into Fe(2+) (PubMed:30272000). Probably functions in dietary iron absorption at the brush border of duodenal enterocytes by producing Fe(2+), the divalent form of iron that can be transported into enterocytes (PubMed:30272000). It is also able to reduce extracellular monodehydro-L-ascorbate and may be involved in extracellular ascorbate regeneration by erythrocytes in blood (PubMed:17068337). May also act as a ferrireductase in airway epithelial cells (Probable). May also function as a cupric transmembrane reductase (By similarity).
Tissue Specificity
Present in erythrocyte membranes (at protein level). Also expressed in respiratory epithelium.
Cellular localization
- Cell membrane
- Multi-pass membrane protein
- Apical cell membrane
- Multi-pass membrane protein
- Localized at the brush border of duodenal cells.
Alternative names
DCYTB, FRRS3, CYBRD1, Plasma membrane ascorbate-dependent reductase CYBRD1, Cytochrome b reductase 1, Duodenal cytochrome b, Ferric-chelate reductase 3