CSF3

Function

Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages. This CSF induces granulocytes.

Post-translational modifications

O-glycan consists of Gal-GalNAc disaccharide which can be modified with up to two sialic acid residues (done in recombinantly expressed G-CSF from CHO cells).

Sequence Similarities

Belongs to the IL-6 superfamily.

Cellular localization

• Secreted

Alternative names

C17orf33, GCSF, CSF3, Granulocyte colony-stimulating factor, G-CSF, Pluripoietin

Database links

swissprot:P09919 entrezGene:1440 omim:138970

Other research areas

• Immunology & Infectious Disease