Csf2ra

Domain

The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.

The box 1 motif is required for JAK interaction and/or activation.

Function

Low affinity receptor for granulocyte-macrophage colony-stimulating factor. Transduces a signal that results in the proliferation, differentiation, and functional activation of hematopoietic cells.

Sequence Similarities

Belongs to the type I cytokine receptor family. Type 5 subfamily.

Cellular localization

• Membrane
• Single-pass type I membrane protein

Alternative names

CD116, Csfgmra, Csf2ra, Granulocyte-macrophage colony-stimulating factor receptor subunit alpha, GM-CSF-R-alpha, GMCSFR-alpha, GMR-alpha

Database links

swissprot:Q00941 entrezGene:12982

Other research areas

• Immuno-oncology