CLEC11A
Developmental stage
In the bone marrow, expression is limited to immature neutrophils. Expression was not detected in circulating mature neutrophils.
Function
Promotes osteogenesis by stimulating the differentiation of mesenchymal progenitors into mature osteoblasts (PubMed:27976999). Important for repair and maintenance of adult bone (By similarity).
Post-translational modifications
O-glycosylated. Probably sulfated on the O-glycans.
Tissue Specificity
Expressed in skeletal tissues including bone marrow, chondrocytes, primary ossification center-associated cells, the perichondrium and periosteum. Lower levels of expression were detected in spleen, thymus, appendix and fetal liver.
Cellular localization
- Cytoplasm
- Secreted
Alternative names
CLECSF3, LSLCL, SCGF, CLEC11A, C-type lectin domain family 11 member A, C-type lectin superfamily member 3, Lymphocyte secreted C-type lectin, Osteolectin, Stem cell growth factor, p47