CLDN5

GeneName

CLDN5

Summary

CLDN5, also known as claudin-5, is a 23 kDa integral membrane protein primarily expressed in endothelial cells, particularly within tight junctions of the blood-brain barrier and other vascular endothelium. It plays a crucial role in the formation and maintenance of tight junctions, which are essential for regulating paracellular permeability and maintaining the integrity of the endothelial barrier. CLDN5 is involved in various cellular processes, including cell adhesion and the assembly of bicellular tight junctions, contributing to the establishment of the blood-retinal barrier and the maintenance of the blood-brain barrier. Its interactions with other proteins at cell junctions facilitate communication and adhesion between adjacent cells.

Importance

CLDN5 is relevant to: - The integrity of the blood-brain barrier, influencing drug delivery and neuroinflammation in neurological disorders. - Vascular biology, particularly in the context of angiogenesis and vascular permeability regulation. - Developmental processes such as morphogenesis and myelination, which are critical for proper tissue formation and function. - Pathological conditions like cancer, where alterations in tight junction integrity can affect tumour progression and metastasis.

Top Products

For researchers investigating CLDN5, we recommend two excellent primary antibodies that cater to different experimental needs. The first is the well-cited polyclonal antibody, Anti-Claudin 5 antibody (ab15106), which has garnered 158 citations and is particularly effective for immunohistochemistry (IHC). This product is a trusted choice for those focusing on tissue samples. In addition, we offer the recombinant antibody, Anti-Claudin 5 antibody [EPR7583] (ab131259), which has been validated for use in Western blotting (WB), IHC, and immunocytochemistry (ICC). With 127 citations, this monoclonal antibody is ideal for researchers seeking the consistency and reliability that recombinant antibodies provide. Together, these products offer a comprehensive toolkit for studying CLDN5 across various applications.

Abcam Product Citation Summary

The data indicates a significant focus on the role of CLDN5 in various endothelial contexts, particularly in studies related to the blood-brain barrier and tight junction integrity. The use of multiple applications, primarily Western blotting and immunofluorescence, highlights the importance of CLDN5 in understanding endothelial cell permeability and the effects of external factors such as methamphetamine and ZnONPs.