Cdkn2a
Function
Acts as a negative regulator of the proliferation of normal cells by interacting strongly with CDK4 and CDK6. This inhibits their ability to interact with cyclins D and to phosphorylate the retinoblastoma protein.
Post-translational modifications
Phosphorylation seems to increase interaction with CDK4.
Sequence Similarities
Belongs to the CDKN2 cyclin-dependent kinase inhibitor family.
Cellular localization
- Cytoplasm
- Nucleus
Alternative names
P16ink4a, Cdkn2a, Cyclin-dependent kinase inhibitor 2A, Cyclin-dependent kinase 4 inhibitor A, p16-INK4a, CDK4I, p16-INK4