Cd48
Function
Glycosylphosphatidylinositol (GPI)-anchored cell surface glycoprotein that interacts via its N-terminal immunoglobulin domain with cell surface receptors including 2B4/CD244 or CD2 to regulate immune cell function and activation (PubMed:21278219, PubMed:9881969). Participates in T-cell signaling transduction by associating with CD2 and efficiently bringing the Src family protein kinase LCK and LAT to the TCR/CD3 complex. In turn, promotes LCK phosphorylation and subsequent activation (PubMed:9881969). Induces the phosphorylation of the cytoplasmic immunoreceptortyrosine switch motifs (ITSMs) of CD244 initiating a series of signaling events that leads to the generation of the immunological synapse and the directed release of cytolytic granules containing perforin and granzymes by T-lymphocytes and NK-cells (By similarity) (PubMed:21278219, PubMed:9881969).
Cellular localization
- Cell membrane
- Lipid-anchor
- GPI-anchor
- Membrane raft
- Secreted
Alternative names
CD48, Bcm-1, Cd48, CD48 antigen, BCM1 surface antigen, BLAST-1, HM48-1, MRC OX-45 surface antigen, SLAM family member 2, Signaling lymphocytic activation molecule 2, sgp-60, SLAMF2