CD1A

Function

Antigen-presenting protein that binds self and non-self lipid and glycolipid antigens and presents them to T-cell receptors on natural killer T-cells.

Tissue Specificity

Expressed on cortical thymocytes, epidermal Langerhans cells, dendritic cells, on certain T-cell leukemias, and in various other tissues.

Cellular localization

• Cell membrane
• Single-pass type I membrane protein
• Membrane raft
• Single-pass type I membrane protein
• Endosome membrane
• Single-pass type I membrane protein
• Subject to intracellular trafficking between the cell membrane and endosomes (PubMed:11231314). Localizes to cell surface lipid rafts (PubMed:18178838).

Alternative names

CD1a, T-cell surface glycoprotein CD1a, T-cell surface antigen T6/Leu-6, hTa1 thymocyte antigen, CD1A

Database links

swissprot:P06126 omim:188370 entrezGene:909

Other research areas

• Immuno-oncology