CD14

Domain

The C-terminal leucine-rich repeat (LRR) region is required for responses to smooth LPS.

Function

Coreceptor for bacterial lipopolysaccharide (PubMed:1698311, PubMed:23264655). In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS) (PubMed:20133493, PubMed:22265692, PubMed:23264655). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (PubMed:8612135). Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell surface and subsequently are targeted to the Golgi in a lipid-raft dependent pathway (PubMed:16880211). Binds electronegative LDL (LDL(-)) and mediates the cytokine release induced by LDL(-) (PubMed:23880187).

Post-translational modifications

N- and O- glycosylated. O-glycosylated with a core 1 or possibly core 8 glycan.

Tissue Specificity

Detected on macrophages (at protein level) (PubMed:1698311). Expressed strongly on the surface of monocytes and weakly on the surface of granulocytes; also expressed by most tissue macrophages.

Cellular localization

• Cell membrane
• Lipid-anchor
• GPI-anchor
• Secreted
• Membrane raft
• Golgi apparatus
• Secreted forms may arise by cleavage of the GPI anchor.

Alternative names

CD14, Monocyte differentiation antigen CD14, My23 antigen, Myeloid cell-specific leucine-rich glycoprotein

Database links

swissprot:P08571 omim:158120 entrezGene:929

Other research areas

• Immuno-oncology