Ccr4
Developmental stage
Low expression at 7.5 dpc and 12.5 dpc in the yolk sac.
Function
High affinity receptor for the C-C type chemokines CCL17/TARC and CCL22/MDC. The activity of this receptor is mediated by G(i) proteins which activate a phosphatidylinositol-calcium second messenger system. Could play a role in lipopolysaccharide (LPS)-induced endotoxic shock. In the CNS, could mediate hippocampal-neuron survival.
Post-translational modifications
In natural killer cells, CCL22 binding induces phosphorylation on yet undefined Ser/Thr residues, most probably by beta-adrenergic receptor kinases 1 and 2.
Sequence Similarities
Belongs to the G-protein coupled receptor 1 family.
Tissue Specificity
Expressed in the thymus, macrophages and T- and B-cells.
Cellular localization
- Cell membrane
- Multi-pass membrane protein
Alternative names
CD194, Cmkbr4, C-C chemokine receptor type 4, C-C CKR-4, CC-CKR-4, CCR-4, CCR4