C3AR1

Function

Receptor for the chemotactic and inflammatory peptide anaphylatoxin C3a. This receptor stimulates chemotaxis, granule enzyme release and superoxide anion production.

Post-translational modifications

Among the sulfation sites Tyr-174 is essential for binding of C3a anaphylatoxin.

O-glycosylated.

Sequence Similarities

Belongs to the G-protein coupled receptor 1 family.

Tissue Specificity

Widely expressed in several differentiated hematopoietic cell lines, in the lung, spleen, ovary, placenta, small intestine, throughout the brain, heart, and endothelial cells. Mostly expressed in lymphoid tissues.

Cellular localization

• Cell membrane
• Multi-pass membrane protein

Alternative names

AZ3B, C3R1, HNFAG09, C3AR1, C3a anaphylatoxin chemotactic receptor, C3AR, C3a-R

Database links

swissprot:Q16581 entrezGene:719 omim:605246

Other research areas

• Immuno-oncology