BMP4
GeneName
BMP4
Summary
BMP4, also known as BMP-4 or bone morphogenetic protein 4, is a secreted protein with a molecular mass of 47 kDa. It is primarily localised in the extracellular region and extracellular matrix, and plays a crucial role in various developmental processes. BMP4 is involved in BMP signalling pathways and is essential for the differentiation of multiple cell types, including osteoblasts, chondrocytes, and cardiac muscle cells. It also influences processes such as angiogenesis, odontogenesis, and the morphogenesis of various organs and tissues, including the lungs and kidneys. BMP4 functions through binding to BMP receptors, exhibiting cytokine and growth factor activities, and is known to act as a chemoattractant. Its diverse roles underscore its importance in embryonic development and tissue homeostasis.
Importance
BMP4 is relevant to: - Developmental biology, particularly in the study of organogenesis and tissue differentiation. - Regenerative medicine, due to its potential in promoting tissue repair and regeneration. - Cancer research, as it may influence tumour microenvironments and cancer cell behaviour. - Understanding congenital disorders linked to aberrant BMP signalling, which can affect skeletal and cardiac development.
Top Products
For researchers investigating BMP4, we recommend two excellent primary antibodies. The first is the well-cited polyclonal antibody, Anti-BMP4 antibody (ab39973), which has garnered 106 citations, reflecting its reliability and trust within the scientific community. This antibody is particularly effective for Western blotting (WB) and immunocytochemistry (ICC). In addition, we offer the recombinant monoclonal antibody, Anti-BMP4 antibody [EPR6211] (ab124715). This versatile product has been validated for a broader range of applications, including WB, immunohistochemistry (IHC), ICC, immunoprecipitation (IP), and flow cytometry (FC). With 32 citations, it is also gaining recognition among researchers. The recombinant nature of this antibody ensures batch-to-batch consistency, making it an excellent choice for those requiring dependable BMP4 detection. The Recombinant human BMP4 protein (Active) ELISA Kit (ab238298), supported by 2 citations, is an excellent option for researchers looking to accurately measure BMP4 levels in their experiments.
Abcam Product Citation Summary
The data indicates that BMP4 is being studied in various contexts, particularly in relation to cancer progression in human hepatocellular carcinoma and fibrotic processes in human lung fibroblasts. Additionally, BMP4 is being investigated in mouse models and rat endothelial cells, highlighting its relevance in studies of dietary effects and signaling pathways. The use of both Western blotting and immunohistochemistry suggests a comprehensive approach to understanding BMP4's role in these biological processes.
Abcam Product Citation Table
Function
Growth factor of the TGF-beta superfamily that plays essential roles in many developmental processes, including neurogenesis, vascular development, angiogenesis and osteogenesis (PubMed:31363885). Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction (By similarity). Initiates the canonical BMP signaling cascade by associating with type I receptor BMPR1A and type II receptor BMPR2 (PubMed:25868050, PubMed:8006002). Once all three components are bound together in a complex at the cell surface, BMPR2 phosphorylates and activates BMPR1A. In turn, BMPR1A propagates signal by phosphorylating SMAD1/5/8 that travel to the nucleus and act as activators and repressors of transcription of target genes (PubMed:25868050, PubMed:29212066). Positively regulates the expression of odontogenic development regulator MSX1 via inducing the IPO7-mediated import of SMAD1 to the nucleus (By similarity). Required for MSX1-mediated mesenchymal molar tooth bud development beyond the bud stage, via promoting Wnt signaling (By similarity). Acts as a positive regulator of odontoblast differentiation during mesenchymal tooth germ formation, expression is repressed during the bell stage by MSX1-mediated inhibition of CTNNB1 signaling (By similarity). Able to induce its own expression in dental mesenchymal cells and also in the neighboring dental epithelial cells via an MSX1-mediated pathway (By similarity). Can also signal through non-canonical BMP pathways such as ERK/MAP kinase, PI3K/Akt, or SRC cascades (PubMed:31363885). For example, induces SRC phosphorylation which, in turn, activates VEGFR2, leading to an angiogenic response (PubMed:31363885).
Involvement in disease
Microphthalmia, syndromic, 6
MCOPS6
A disease characterized by microphthalmia/anophthalmia associated with facial, genital, skeletal, neurologic and endocrine anomalies. Microphthalmia is a disorder of eye formation, ranging from small size of a single eye to complete bilateral absence of ocular tissues (anophthalmia). In many cases, microphthalmia/anophthalmia occurs in association with syndromes that include non-ocular abnormalities.
None
The disease is caused by variants affecting the gene represented in this entry.
Non-syndromic orofacial cleft 11
OFC11
A birth defect consisting of cleft lips with or without cleft palate. Cleft lips are associated with cleft palate in two-third of cases. A cleft lip can occur on one or both sides and range in severity from a simple notch in the upper lip to a complete opening in the lip extending into the floor of the nostril and involving the upper gum.
None
The disease is caused by variants affecting the gene represented in this entry.
Sequence Similarities
Belongs to the TGF-beta family.
Tissue Specificity
Expressed in the lung and lower levels seen in the kidney. Present also in normal and neoplastic prostate tissues, and prostate cancer cell lines.
Cellular localization
- Secreted
- Extracellular space
- Extracellular matrix
Alternative names
BMP2B, DVR4, BMP4, Bone morphogenetic protein 4, BMP-4, Bone morphogenetic protein 2B, BMP-2B