BDNF

GeneName

BDNF

Summary

BDNF, also known as brain derived neurotrophic factor or proBDNF, is a 28 kDa secreted protein that plays a vital role in the development and maintenance of the nervous system. It is predominantly expressed in the brain and is localised in various cellular components including axons, dendrites, and synaptic vesicles. BDNF functions as a growth factor, promoting neuron survival, differentiation, and growth, and is involved in synaptic plasticity and modulation of chemical synaptic transmission. It binds to specific receptors, initiating signalling pathways that are crucial for nerve development and guidance, as well as the regulation of apoptotic processes in neurons.

Importance

BDNF is relevant to: - Neurodevelopmental disorders, as it influences neuronal survival and differentiation during brain development. - Neurodegenerative diseases, due to its role in promoting neuronal health and function. - Mental health conditions, such as depression and anxiety, where altered BDNF levels have been implicated. - Synaptic plasticity and learning processes, as it is essential for long-term potentiation and memory formation.

Top Products

For researchers investigating BDNF, we highly recommend the top-selling recombinant antibody, Anti-BDNF antibody [EPR1292] (ab108319). This antibody has been validated in a variety of applications, including Western blotting (WB), immunohistochemistry (IHC), immunocytochemistry (ICC), and flow cytometry (FC), making it a versatile tool for your research needs. With 672 citations, it is well-regarded in the scientific community, reflecting its reliability and effectiveness in BDNF detection. This product is an excellent choice for those seeking the consistency and performance that recombinant antibodies offer. The Recombinant human BDNF protein (Animal Free) ELISA Kit (ab222178) is an excellent option for researchers looking to measure BDNF levels with confidence, supported by its citation in the literature.

Abcam Product Citation Summary

The data indicates a significant focus on the role of BDNF in various neurological contexts, particularly in studies involving rat and mouse models. The applications primarily involve Western blotting, highlighting the importance of BDNF in neuroprotection, synaptic function, and neurogenesis. Additionally, the studies explore the effects of pharmacological treatments and environmental factors on BDNF expression, suggesting its critical role in brain health and disease.

Abcam Product Citation Table

Function

Important signaling molecule that activates signaling cascades downstream of NTRK2 (PubMed:11152678). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including long-term potentiation (LTP), long-term depression (LTD), certain forms of short-term synaptic plasticity, as well as homeostatic regulation of intrinsic neuronal excitability.

Neurotrophic factor BDNF precursor form

Important signaling molecule that activates signaling cascades downstream of NTRK2. Activates signaling cascades via the heterodimeric receptor formed by NGFR and SORCS2 (PubMed:24908487, PubMed:29909994). Signaling via NGFR and SORCS2 plays a role in synaptic plasticity and long-term depression (LTD). Binding to NGFR and SORCS2 promotes neuronal apoptosis. Promotes neuronal growth cone collapse (By similarity).

Post-translational modifications

Neurotrophic factor BDNF precursor form

N-glycosylated and glycosulfated, contrary to mature BDNF.

Mature BDNF is produced by proteolytic removal of the propeptide, catalyzed by a FURIN family member. In addition, the precursor form is proteolytically cleaved within the propeptide, but this is not an obligatory intermediate for the production of mature BDNF (PubMed:11152678). Can be converted into mature BDNF by plasmin (PLG) (PubMed:19467646).

Sequence Similarities

Belongs to the NGF-beta family.

Tissue Specificity

Detected in blood plasma and in saliva (at protein level) (PubMed:11152678, PubMed:19467646). Brain. Highly expressed in hippocampus, amygdala, cerebral cortex and cerebellum. Also expressed in heart, lung, skeletal muscle, testis, prostate and placenta.

Cellular localization

• Secreted
• Neurotrophic factor BDNF precursor form
• Secreted
• A proportion of BDNF is secreted as immature precursor (proBDNF).

Alternative names

Neurotrophic factor BDNF precursor form, proBDNF, Abrineurin, Brain-derived neurotrophic factor, BDNF

Database links

swissprot:P23560 omim:113505 entrezGene:627

Other research areas

• Cardiovascular