ATP1B1
Domain
The C-terminal lobe folds into an immunoglobulin-like domain and mediates cell adhesion properties.
Function
This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane (PubMed:19694409). Plays a role in innate immunity by enhancing virus-triggered induction of interferons (IFNs) and interferon stimulated genes (ISGs). Mechanistically, enhances the ubiquitination of TRAF3 and TRAF6 as well as the phosphorylation of TAK1 and TBK1 (PubMed:34011520).
Involved in cell adhesion and establishing epithelial cell polarity.
Post-translational modifications
Glutathionylated (By similarity). N-glycosylated (By similarity).
Sequence Similarities
Belongs to the X(+)/potassium ATPases subunit beta family.
Tissue Specificity
Found in most tissues.
Cellular localization
- Cell membrane
- Single-pass type II membrane protein
- Apical cell membrane
- Single-pass type II membrane protein
- Cell membrane
- Sarcolemma
- Colocalizes with OBSCN at the intercalated disk and sarcolemma in cardiomyocytes. Localizes in long striations at the level of Z and M lines.
Alternative names
ATP1B, ATP1B1, Sodium/potassium-transporting ATPase subunit beta-1, Sodium/potassium-dependent ATPase subunit beta-1