ARL11
Function
May play a role in apoptosis. May act as a tumor suppressor.
Involvement in disease
Leukemia, chronic lymphocytic
CLL
A chronic leukemia in which functionally incompetent B-lymphocytes progressively accumulate in the bone marrow, blood, and lymphoid tissues. The clinical evolution of the disorder is heterogeneous, with some patients having indolent disease and others having aggressive disease and short survival.
None
Disease susceptibility is associated with variants affecting the gene represented in this entry.
Sequence Similarities
Belongs to the small GTPase superfamily. Arf family.
Tissue Specificity
Expressed in lung and leukocytes.
Alternative names
ARLTS1, ARL11, ADP-ribosylation factor-like protein 11, ADP-ribosylation factor-like tumor suppressor protein 1