ALDH9A1
Developmental stage
Strongly expressed in human embryonic brain (gestational age 12 weeks).
Function
Converts gamma-trimethylaminobutyraldehyde into gamma-butyrobetaine with high efficiency (in vitro). Can catalyze the irreversible oxidation of a broad range of aldehydes to the corresponding acids in an NAD-dependent reaction, but with low efficiency. Catalyzes the oxidation of aldehydes arising from biogenic amines and polyamines.
Pathway
Amine and polyamine biosynthesis; carnitine biosynthesis.
Sequence Similarities
Belongs to the aldehyde dehydrogenase family.
Tissue Specificity
Detected in brain (at protein level) (PubMed:8645224). High expression in adult liver, skeletal muscle, and kidney. Low levels in heart, pancreas, lung and brain (PubMed:8786138). Expressed in all regions of the brain. Expression levels are variable in the different brain areas, with the highest levels in the spinal cord and the lowest in the occipital pole.
Cellular localization
- Cytoplasm
- Cytosol
- Cytoplasm
Alternative names
ALDH4, ALDH7, ALDH9, ALDH9A1, 4-trimethylaminobutyraldehyde dehydrogenase, TMABA-DH, TMABALDH, Aldehyde dehydrogenase E3 isozyme, Aldehyde dehydrogenase family 9 member A1, Formaldehyde dehydrogenase, Gamma-aminobutyraldehyde dehydrogenase, R-aminobutyraldehyde dehydrogenase