Anti-TPN抗体(ab13518)
Key features and details
- Rabbit polyclonal to TPN
- Suitable for: WB, IP
- Reacts with: Human
- Isotype: IgG
选择批间可重复性更高的重组抗体
- 研究可靠 —— 各批次间结果一致且可重复
- 长期批量供应 —— 采用重组技术,可实现快速生产
- 首次实验即可成功 —— 经过大量验证确认了特异性
- 符合伦理标准 —— 产品不含动物成分
概述
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产品名称
Anti-TPN抗体
参阅全部 TPN 一抗 -
描述
兔多克隆抗体to TPN -
宿主
Rabbit -
特异性
Weakly cross-reacts with bovine Tapasin.
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经测试应用
适用于: WB, IPmore details -
种属反应性
与反应: Human
预测可用于: Cow -
免疫原
Synthetic peptide corresponding to Human TPN aa 430-448.
Sequence:LGWAAVYLSTCKDSKKKAE
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
存储溶液
Preservative: 0.09% Sodium azide
Constituents: PBS, 50% Glycerol (glycerin, glycerine) -
Concentration information loading...
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纯度
Protein A purified -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
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Recombinant Protein
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab13518于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
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WB | (1) |
Use at an assay dependent concentration. Predicted molecular weight: 48 kDa.
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IP |
Use at an assay dependent concentration.
|
说明 |
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WB
Use at an assay dependent concentration. Predicted molecular weight: 48 kDa. |
IP
Use at an assay dependent concentration. |
靶标
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功能
Involved in the association of MHC class I with transporter associated with antigen processing (TAP) and in the assembly of MHC class I with peptide (peptide loading). -
组织特异性
Neutrophils, mostly in fully differentiated cells. -
序列相似性
Contains 1 Ig-like C1-type (immunoglobulin-like) domain. -
结构域
The N-terminus is required for efficient association with MHC class I molecule and for a stable interaction between MHC I and calreticulin. Binding to TAP is mediated by the C-terminus region. -
细胞定位
Endoplasmic reticulum membrane. - Information by UniProt
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数据库链接
- Entrez Gene: 6892 Human
- Omim: 601962 Human
- SwissProt: O15533 Human
- Unigene: 370937 Human
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别名
- NGS 17 antibody
- NGS-17 antibody
- NGS17 antibody
see all
数据表及文件
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SDS download
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Datasheet download
文献 (7)
ab13518 被引用在 7 文献中.
- Domnick A et al. Molecular basis of MHC I quality control in the peptide loading complex. Nat Commun 13:4701 (2022). PubMed: 35948544
- Wang KW et al. An antigen processing and presentation signature for prognostic evaluation and immunotherapy selection in advanced gastric cancer. Front Immunol 13:992060 (2022). PubMed: 36311733
- Liang YH et al. Chemotherapy agents stimulate dendritic cells against human colon cancer cells through upregulation of the transporter associated with antigen processing. Sci Rep 11:9080 (2021). PubMed: 33907276
- Lazaridou MF et al. Identification of miR-200a-5p targeting the peptide transporter TAP1 and its association with the clinical outcome of melanoma patients. Oncoimmunology 9:1774323 (2020). PubMed: 32923135
- Wynne JW et al. Characterization of the Antigen Processing Machinery and Endogenous Peptide Presentation of a Bat MHC Class I Molecule. J Immunol 196:4468-76 (2016). PubMed: 27183594
- Del Campo AB et al. Adenovirus expressing ß2-microglobulin recovers HLA class I expression and antitumor immunity by increasing T-cell recognition. Cancer Gene Ther N/A:N/A (2014). PubMed: 24971583
- Chapiro J et al. Destructive cleavage of antigenic peptides either by the immunoproteasome or by the standard proteasome results in differential antigen presentation. J Immunol 176:1053-61 (2006). WB ; Human . PubMed: 16393993