Anti-TAG72抗体[B72.3] (ab691)
Key features and details
- Mouse monoclonal [B72.3] to TAG72
- Suitable for: IHC-P, IHC-Fr
- Reacts with: Rat, Hamster, Human
- Isotype: IgG1
概述
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产品名称
Anti-TAG72抗体[B72.3] -
描述
小鼠单克隆抗体[B72.3] to TAG72 -
宿主
Mouse -
特异性
This antibody recognises an oncofetal antigen of >1,000kDa, identified as a Tumor-Associated Glycoprotein (TAG-72) with the properties of a mucin. Weak or no reactivity has been observed with most cell types of normal adult tissue excepting the secretory endometrium. -
经测试应用
适用于: IHC-P, IHC-Frmore details -
种属反应性
与反应: Rat, Hamster, Human -
免疫原
Tissue, cells or virus corresponding to TAG72. Membrane-enriched fraction of a human breast carcinoma liver metastasis
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阳性对照
- Lung carcinoma or breast cancer.
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
存储溶液
Preservative: 0.1% Sodium azide
Constituent: 99% Water
Proprietary preservative that is not sodium azide or thimerosal, protein carrier. -
无载体
是 -
Concentration information loading...
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克隆
单克隆 -
克隆编号
B72.3 -
骨髓瘤
P3-NS1/1-Ag4-1 -
同种型
IgG1 -
轻链类型
kappa -
研究领域
相关产品
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Antibody Diluent
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Compatible Secondaries
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Isotype control
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Unmasking reagent
应用
应用 | Ab评论 | 说明 |
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IHC-P |
1/50 - 1/100. Perform enzymatic antigen retrieval before commencing with IHC staining protocol. Incubation for 30-60 minutes at room temperature is recommended.
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IHC-Fr |
Use at an assay dependent concentration.
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说明 |
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IHC-P
1/50 - 1/100. Perform enzymatic antigen retrieval before commencing with IHC staining protocol. Incubation for 30-60 minutes at room temperature is recommended. |
IHC-Fr
Use at an assay dependent concentration. |
靶标
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相关性
The majority of human adenocarcinomas including colorectal, pancreatic, gastric, ovarian, endometrial, mammary, and non-small cell lung cancer display some cell populations that are positive for TAG72. About 60% of carcinoma patients express TAG72 in their sera. TAG72 is reportedly useful in distinguishing pulmonary adenocarcinomas from pleural mesotheliomas. -
细胞定位
Cytoplasmic -
别名
- CA 72.4 antibody
- CA72.4 antibody
- TAG 72 antibody
- Tumor associated glycoprotein 72 antibody
图片
数据表及文件
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SDS download
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Datasheet download
文献 (15)
ab691 被引用在 15 文献中.
- Cotton S et al. Target Score-A Proteomics Data Selection Tool Applied to Esophageal Cancer Identifies GLUT1-Sialyl Tn Glycoforms as Biomarkers of Cancer Aggressiveness. Int J Mol Sci 22:N/A (2021). PubMed: 33562270
- Persson N et al. Epitope mapping of a new anti-Tn antibody detecting gastric cancer cells. Glycobiology 27:635-645 (2017). PubMed: 28419225
- Tamura F et al. RNAi-mediated gene silencing of ST6GalNAc I suppresses the metastatic potential in gastric cancer cells. Gastric Cancer 19:85-97 (2016). PubMed: 25532910
- Xu F et al. Expression profile of mucin-associated sialyl-Tn antigen in Chinese patients with different colorectal lesions (adenomas, carcinomas). Int J Clin Exp Pathol 8:11549-54 (2015). PubMed: 26617889
- van Niekerk CC et al. Differentiation margins of ovarian tumor pathology: first incidences of epithelial ovarian tumors monitored by marker antibodies. Cancer Detect Prev 21:247-57 (1997). PubMed: 9167042