Key features and details
- Rabbit polyclonal to Synapsin I - Synaptic Marker
- Suitable for: WB
- Reacts with: Mouse, Rat, Guinea pig, Cow, Human
- Isotype: IgG
存放说明Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Constituents: 0.24% HEPES, 0.87% Sodium chloride, 0.0001% BSA, 50% Glycerol
Concentration information loading...
纯度Immunogen affinity purified
Our Abpromise guarantee covers the use of ab8 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|WB||1/1000. Predicted molecular weight: 80 kDa.|
功能Neuronal phosphoprotein that coats synaptic vesicles, binds to the cytoskeleton, and is believed to function in the regulation of neurotransmitter release. The complex formed with NOS1 and CAPON proteins is necessary for specific nitric-oxid functions at a presynaptic level.
疾病相关Defects in SYN1 are a cause of epilepsy X-linked with variable learning disabilities and behavior disorders [MIM:300491]. XELBD is characterized by variable combinations of epilepsy, learning difficulties, macrocephaly, and aggressive behavior.
序列相似性Belongs to the synapsin family.
翻译后修饰Substrate of at least four different protein kinases. It is probable that phosphorylation plays a role in the regulation of synapsin-1 in the nerve terminal. Phosphorylated upon DNA damage, probably by ATM or ATR.
细胞定位Cell junction > synapse. Golgi apparatus.
- Information by UniProt
- Brain protein 4.1 antibody
- SYN 1 antibody
- SYN 1a antibody
Anti-Synapsin I antibody - Synaptic Marker (ab8) + Rat brain tissue lysate at 10 µg
Predicted band size: 80 kDa
Observed band size: 78 kDa why is the actual band size different from the predicted?
ab8 被引用在 36 文献中.
- Liu X et al. miR-134-5p/Foxp2/Syn1 is involved in cognitive impairment in an early vascular dementia rat model. Int J Mol Med 44:1729-1740 (2019). PubMed: 31545395
- Kullmann FA et al. Serotonergic paraneurones in the female mouse urethral epithelium and their potential role in peripheral sensory information processing. Acta Physiol (Oxf) 222:N/A (2018). PubMed: 28719042
- Hansen SN et al. Long term Westernized diet leads to region-specific changes in brain signaling mechanisms. Neurosci Lett 676:85-91 (2018). WB ; Guinea pig . PubMed: 29655945
- Hansen SN et al. Early Life Vitamin C Deficiency Does Not Alter Morphology of Hippocampal CA1 Pyramidal Neurons or Markers of Synaptic Plasticity in a Guinea Pig Model. Nutrients 10:N/A (2018). PubMed: 29890692
- Xie X et al. ß-actin regulates a heterochromatin landscape essential for optimal induction of neuronal programs during direct reprograming. PLoS Genet 14:e1007846 (2018). PubMed: 30557298