Anti-Sprouty 4/Spry-4抗体(ab115557)
Key features and details
- Rabbit polyclonal to Sprouty 4/Spry-4
- Suitable for: IHC-P
- Reacts with: Human
- Isotype: IgG
概述
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产品名称
Anti-Sprouty 4/Spry-4抗体
参阅全部 Sprouty 4/Spry-4 一抗 -
描述
兔多克隆抗体to Sprouty 4/Spry-4 -
宿主
Rabbit -
经测试应用
适用于: IHC-Pmore details -
种属反应性
与反应: Human -
免疫原
Synthetic peptide corresponding to Human Sprouty 4/Spry-4 aa 300-400 (C terminal) conjugated to keyhole limpet haemocyanin.
Database link: NP_112226.2 -
阳性对照
- Human Heart tissue.
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles. -
存储溶液
pH: 7.20
Preservative: 0.01% Sodium azide
Constituents: 0.424% Potassium phosphate, 0.88% Sodium chloride -
Concentration information loading...
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纯度
Protein A purified -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab115557于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
---|---|---|
IHC-P | (1) |
Use a concentration of 2.5 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
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说明 |
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IHC-P
Use a concentration of 2.5 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol. |
靶标
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功能
Suppresses the insulin receptor and EGFR-transduced MAPK signaling pathway, but does not inhibit MAPK activation by a constitutively active mutant Ras. Probably impairs the formation of GTP-Ras. -
序列相似性
Belongs to the sprouty family.
Contains 1 SPR (sprouty) domain. -
结构域
The Cys-rich domain is responsible for the localization of the protein to the membrane ruffles. -
细胞定位
Cytoplasm. Cell projection > ruffle membrane. - Information by UniProt
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数据库链接
- Entrez Gene: 81848 Human
- Omim: 607984 Human
- SwissProt: Q9C004 Human
- Unigene: 323308 Human
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别名
- Protein sprouty homolog 4 antibody
- Sprouty 4 antibody
- Sprouty homolog 4 antibody
see all
图片
数据表及文件
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SDS download
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Datasheet download
文献 (1)
ab115557 被引用在 1 文献中.
- Brock EJ et al. Sprouty4 negatively regulates ERK/MAPK signaling and the transition from in situ to invasive breast ductal carcinoma. PLoS One 16:e0252314 (2021). PubMed: 34048471