Sotrastaurin,pan-PKC抑制剂(ab219867)
Key features and details
- Potent, selective pan-PKC inhibitor
- CAS Number: 425637-18-9
- Purity: > 99%
- Form / State: Solid
- Source: Synthetic
概述
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产品名称
Sotrastaurin,pan-PKC抑制剂 -
描述
Potent,selective pan-PKC抑制剂 -
别名
- 3-(1H-indol-3-yl)-4-(2-(4-methylpiperazin-1-yl)quinazolin-4-yl)-1H-pyrrole-2,5-dione
- AEB071
- NVP-AEB071
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生物学描述
Potent, selective pan-PKC inhibitor (Ki values of 0.95, 0.64, 2.1, 3.2, 1.8, and 0.22 nM for PKCα, βI, δ, ε, η, and θ respectively in a cell-free assay). Prevents the production of various cytokines by activated T cells, macrophages, and keratinocytes in vitro and has been shown to inhibit an acute allergic contact dermatitis response in rats when dosed orally at 30 mg. Displays potential immunosuppressive activity.
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纯度
> 99% -
CAS编号
425637-18-9 -
化学结构
性能
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分子量
438.48 -
分子式
C25H22N6O2 -
PubChem识别号
10296883 -
存放说明
Store at -20°C. Store under desiccating conditions. -
SMILES
CN1CCN(CC1)C2=NC3=CC=CC=C3C(=N2)C4=C(C(=O)NC4=O)C5=CNC6=CC=CC=C65 -
来源
Synthetic
实验方案
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
数据表及文件
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SDS download
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Datasheet download
文献 (0)
ab219867 尚未被引用在任何文献中。