Synthetic peptide (acetyl K68). The exact sequence is proprietary. Database link: P04179 (Peptide available as ab176149)
WB: Transfected 293T lysate.
IHC-P: Human cervical carcinoma tissue and Human muscle tissue.
This antibody was developed as part of a collaboration with the lab of David Guis at Vanderbilt University.
Use our conjugation kits for antibody conjugates that are ready-to-use in as little as 20 minutes with <1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMab® patents
This product is a recombinant rabbit monoclonal antibody.
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.
Genetic variation in SOD2 is associated with susceptibility to microvascular complications of diabetes type 6 (MVCD6) [MIM:612634]. These are pathological conditions that develop in numerous tissues and organs as a consequence of diabetes mellitus. They include diabetic retinopathy, diabetic nephropathy leading to end-stage renal disease, and diabetic neuropathy. Diabetic retinopathy remains the major cause of new-onset blindness among diabetic adults. It is characterized by vascular permeability and increased tissue ischemia and angiogenesis.
Belongs to the iron/manganese superoxide dismutase family.
Nitrated under oxidative stress. Nitration coupled with oxidation inhibits the catalytic activity.
Gurt I et al. The Sirt1 Activators SRT2183 and SRT3025 Inhibit RANKL-Induced Osteoclastogenesis in Bone Marrow-Derived Macrophages and Down-Regulate Sirt3 in Sirt1 Null Cells. PLoS One10:e0134391 (2015).
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