Anti-SmarcAL1抗体(ab4743)
Key features and details
- Rabbit polyclonal to SmarcAL1
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG
概述
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产品名称
Anti-SmarcAL1抗体
参阅全部 SmarcAL1 一抗 -
描述
兔多克隆抗体to SmarcAL1 -
宿主
Rabbit -
特异性
This antibody detects a band at 105kD which corresponds to SmarcAL1. It also detects several lower weight bands of unknown identity. -
经测试应用
适用于: WBmore details -
种属反应性
与反应: Human -
免疫原
Synthetic peptide:
SNADQRPHDSHSFQAKGC
, corresponding to amino acids 80-96 of Human SmarcAL1.
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. -
存储溶液
pH: 7.20
Preservative: 0.01% Sodium azide
Constituents: 0.42% Potassium phosphate, 0.87% Sodium chloride -
Concentration information loading... -
纯度
Immunogen affinity purified -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
应用
Our Abpromise guarantee covers the use of ab4743 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
| 应用 | Ab评论 | 说明 |
|---|---|---|
| WB | 1/500. Detects a band of approximately 105 kDa (predicted molecular weight: 105 kDa). |
靶标
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功能
ATP-dependent annealing helicase that catalyzes the rewinding of the stably unwound DNA. Rewinds single-stranded DNA bubbles that are stably bound by replication protein A (RPA). Acts throughout the genome to reanneal stably unwound DNA, performing the opposite reaction of many enzymes, such as helicases and polymerases, that unwind DNA. -
组织特异性
Ubiquitously expressed, with high levels in testis. -
疾病相关
Defects in SMARCAL1 are a cause of Schimke immuno-osseous dysplasia (SIOD) [MIM:242900]. SIOD causes spondyloepiphyseal dysplasia, renal dysfunction and T-cell immunodeficiency. Approximately half of all patients also exhibit hyperthyroidism, while around half also exhibit episodal cerebral ischema. -
序列相似性
Belongs to the SNF2/RAD54 helicase family. SMARCAL1 subfamily.
Contains 2 HARP domains.
Contains 1 helicase ATP-binding domain.
Contains 1 helicase C-terminal domain. -
细胞定位
Nucleus. - Information by UniProt
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数据库链接
- Entrez Gene: 50485 Human
- Omim: 606622 Human
- SwissProt: Q9NZC9 Human
- Unigene: 516674 Human
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别名
- HARP antibody
- HepA Related Protein antibody
- HepA-related protein antibody
see all
图片
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Western blot - Anti-SmarcAL1 antibody (ab4743)Western blot using ab4743 at 1/500.
Lane 1: Hela nuclear
Lane 2: Hela
Lane 3: A431
Lane 4: Jurkat
Lane 5: 293SmarcAL1 is the band seen between the 97 and 116kD markers.
Secondary antibody: Goat polyclonal to Rabbit IgG H&L (HRP) Pre-Adsorbed ab7090 (1/5000)
Western blot using ab4743 at 1/500.
Exposure time: 1 minute
Cell lysates: 5µ
Lane 1: Hela nuclear
Lane 2: Hela
Lane 3: A431
Lane 4: Jurkat
Lane 5: 293
SmarcAL1 is the band seen between the 97 and 116kD markers.
Secondary antibody: Goat polyclonal to Rabbit IgG H&L (HRP) Pre-Adsorbed ab7090 (1/5000)
Exposure time: 1 minute
Cell lysates: 5µg per lane.
数据表及文件
文献 (0)
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