Key features and details
- Mouse monoclonal [SLAM.4] to SLAM / CD150
- Suitable for: IP, ICC, Flow Cyt
- Reacts with: Human
- Isotype: IgG1
存放说明Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term.
Constituent: 99% PBS
Concentration information loading...
纯度Protein A purified
纯化说明Purified from hybridoma culture supernatant by protein A-affinity chromatography. Purity: > 95% (by SDS-PAGE). 0.2 µm filter sterilized.
Our Abpromise guarantee covers the use of ab130423 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|IP||Use at an assay dependent concentration.|
|ICC||Use at an assay dependent concentration.|
|Flow Cyt||Use at an assay dependent concentration.
ab170190 - Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody.
功能High-affinity self-ligand important in bidirectional T-cell to B-cell stimulation. SLAM-induced signal-transduction events in T-lymphocytes are different from those in B-cells. Two modes of SLAM signaling are likely to exist: one in which the inhibitor SH2D1A acts as a negative regulator and another in which protein-tyrosine phosphatase 2C (PTPN11)-dependent signal transduction operates.
组织特异性Constitutively expressed on peripheral blood memory T-cells, T-cell clones, immature thymocytes and a proportion of B-cells, and is rapidly induced on naive T-cells after activation.
序列相似性Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
Contains 1 Ig-like V-type (immunoglobulin-like) domain.
结构域The most membrane-proximal SH2-binding motif interacts with SH2 domain of SH2D1A and does not need to be phosphorylated on tyrosine residues.
翻译后修饰Phosphorylated by FYN.
细胞定位Cell membrane. Present on the surface of B-cells and T-cells.
- Information by UniProt
- 4933415F16 antibody
- AA177906 antibody
- CD 150 antibody