Anti-SerpinB6/CAP抗体(ab97330)
Key features and details
- Rabbit polyclonal to SerpinB6/CAP
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG
概述
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产品名称
Anti-SerpinB6/CAP抗体
参阅全部 SerpinB6/CAP 一抗 -
描述
兔多克隆抗体to SerpinB6/CAP -
宿主
Rabbit -
经测试应用
适用于: WBmore details -
种属反应性
与反应: Human -
免疫原
Recombinant fragment corresponding to Human SerpinB6/CAP aa 66-283.
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阳性对照
- A549 and HeLa whole cell lysates; HepG2 and HCT116 cell lysates
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
存储溶液
pH: 7.00
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 1.21% Tris, 0.75% Glycine, 20% Glycerol (glycerin, glycerine) -
Concentration information loading...
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纯度
Immunogen affinity purified -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
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Positive Controls
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Recombinant Protein
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab97330于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
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WB |
1/500 - 1/3000. Predicted molecular weight: 42 kDa.
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说明 |
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WB
1/500 - 1/3000. Predicted molecular weight: 42 kDa. |
靶标
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功能
May be involved in the regulation of serine proteinases present in the brain or extravasated from the blood (By similarity). Inhibitor of cathepsin G, kallikrein-8 and thrombin. May play an important role in the inner ear in the protection against leakage of lysosomal content during stress and loss of this protection results in cell death and sensorineural hearing loss. -
组织特异性
Expressed in keratinocytes (at protein level). Highest levels in skeletal muscle. Also found in placenta, cardiac muscle, lung, liver, kidney and pancreas. Expressed in the inner ear hair cells. Expressed abundantly by normal mast cells in different tissues and by mast cells in mastocytoma lesions. -
疾病相关
Defects in SERPINB6 are the cause of deafness autosomal recessive type 91 (DFNB91) [MIM:613453]. It is a form of non-syndromic deafness characterized by progressive and age-dependent sensorineural hearing loss. Vestibular function is normal. -
序列相似性
Belongs to the serpin family. Ov-serpin subfamily. -
细胞定位
Cytoplasm. - Information by UniProt
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数据库链接
- Entrez Gene: 5269 Human
- Omim: 173321 Human
- SwissProt: P35237 Human
- Unigene: 519523 Human
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别名
- CAP antibody
- Cytoplasmic antiproteinase antibody
- Peptidase inhibitor 6 antibody
see all
图片
数据表及文件
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SDS download
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Datasheet download
文献 (1)
ab97330 被引用在 1 文献中.
- Ben-Lulu S et al. Nitrosothiol-Trapping-Based Proteomic Analysis of S-Nitrosylation in Human Lung Carcinoma Cells. PLoS One 12:e0169862 (2017). PubMed: 28081246