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Neuroscience Neurotransmitter Biogenic Amines Serotonin / 5HT

Anti-Serotonin抗体(ab6444)

  • Datasheet
Reviews (1)Q&A (1)References (1)

Product price, shipping and contact information

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送货和订单信息

Abpromise

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Key features and details

  • Rabbit polyclonal to Serotonin
  • Suitable for: ELISA, ICC
  • Reacts with: Species independent
  • Isotype: IgG

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概述

  • 产品名称

    Anti-Serotonin抗体
    参阅全部 Serotonin 一抗
  • 描述

    兔多克隆抗体to Serotonin
  • 宿主

    Rabbit
  • 经测试应用

    适用于: ELISA, ICCmore details
  • 种属反应性

    与反应: Species independent
  • 免疫原

    Chemical/ Small Molecule corresponding to Serotonin. Synthetic 5-Hydroxytryptamine conjugated to protein carrier (PC)

  • 常规说明

    ab6444 specific to conjugated 5-Hydroxytryptamine (Serotonin)

    Reproducibility is key to advancing scientific discovery and accelerating scientists’ next breakthrough.

    Abcam is leading the way with our range of recombinant antibodies, knockout-validated antibodies and knockout cell lines, all of which support improved reproducibility.

    We are also planning to innovate the way in which we present recommended applications and species on our product datasheets, so that only applications & species that have been tested in our own labs, our suppliers or by selected trusted collaborators are covered by our Abpromise™ guarantee.

    In preparation for this, we have started to update the applications & species that this product is Abpromise guaranteed for.

    We are also updating the applications & species that this product has been “predicted to work with,” however this information is not covered by our Abpromise guarantee.

    Applications & species from publications and Abreviews that have not been tested in our own labs or in those of our suppliers are not covered by the Abpromise guarantee.

    Please check that this product meets your needs before purchasing. If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, as well as customer reviews and Q&As.

性能

  • 形式

    Liquid
  • 存放说明

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • Concentration information loading...
  • 纯度

    Ammonium Sulphate Precipitation
  • 克隆

    多克隆
  • 同种型

    IgG
  • 研究领域

    • Neuroscience
    • Neurotransmitter
    • Biogenic Amines
    • Serotonin / 5HT

相关产品

  • Compatible Secondaries

    • Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (ab150077)
    • Goat Anti-Rabbit IgG H&L (HRP) (ab205718)
  • Isotype control

    • Rabbit IgG, polyclonal - Isotype Control (ChIP Grade) (ab171870)

应用

Our Abpromise guarantee covers the use of ab6444 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ELISA Use at an assay dependent concentration.
ICC Use at an assay dependent concentration.

靶标

  • 相关性

    Serotonin (5-hydroxytryptamine, or 5-HT) is a monoamine neurotransmitter synthesised in serotonergic neurons in the central nervous system and enterochromaffin cells in the gastrointestinal tract. Serotonin plays an important part in the biochemistry of depression, migraine, bipolar disorder and anxiety. It is also believed to be influential on sexuality and appetite. 5-HT is generally thought not to be released from synaptic terminal buttons in the manner of classical neurotransmission but from serotonergic varacosities into the extra neuronal space. From here it is free to diffuse over a relatively large region of space (>20µm) and activate 5-HT receptors located on the dendrites, cell bodies and presynaptic terminals of adjacent neurons. Serotonergic action is terminated primarily via uptake of 5-HT from the synapse. This is through the specific monoamine transporter for 5-HT, 5-HT reuptake transporter, on the presynaptic neuron. The pharmacology of 5-HT is extremely complex, with its actions being mediated by a large and diverse range of 5-HT receptors.
  • 细胞定位

    Cytoplasmic and Secreted
  • 别名

    • 5 hydroxytryptamine antibody
    • 5HT antibody

实验方案

  • Immunohisto and cytochemistry

Click here to view the general protocols

数据表及文件

    • Datasheet
  • 文献 (1)

    发表研究结果有使用 ab6444?请让我们知道,以便我们可以引用本数据表中的参考文章。

    ab6444 被引用在 1 文献中.

    • Chen Y  et al. Stress inhibits tryptophan hydroxylase expression in a rat model of depression. Oncotarget 8:63247-63257 (2017). PubMed: 28968985

    客户评价及客户问答

    Show All 评价 Q&A
    提交评价 提交问题

    1-2 of 2 Abreviews or Q&A

    Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) abreview for Anti-Serotonin antibody

    Good
    Abreviews
    Abreviews
    abreview image
    Application
    Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
    Sample
    Mouse Tissue sections (Colon)
    Antigen retrieval step
    Heat mediated - Buffer/Enzyme Used: citrate buffer pH6.0
    Permeabilization
    No
    Specification
    Colon
    Blocking step
    hydrogen peroxide as blocking agent for 15 minute(s) · Concentration: 3% · Temperature: 24°C
    Fixative
    Formaldehyde
    Read More

    Vinicius Kannen Cardoso

    Verified customer

    提交于 Aug 10 2016

    Question

    The immunogen is listed asbeing conjugated toan NO2 group. Do you know the position of this conjugated nitro group? Is it conjugated to the N-terminus of the serotonin? Is it nitro-serotonin or does it block the amino group?

    Read More

    Abcam community

    Verified customer

    Asked on Feb 20 2012

    Answer

    Thank you for your call last week and for your patience while I have been in touch with the lab regarding your enquiry.

    There is a mistake on the datasheet, and the antibody was raised against serotonin conjugated to a protein carrier atthe amino terminus. There was no nitro group in the immunogen. I will have the datasheet updated as soon as possible, and I apologize for this error and any confusion.

    Please let me know if you have any questions or if there is anything else that you need and I'll be happy to help further.

    Read More

    Abcam Scientific Support

    回复于 Feb 20 2012

    Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES"
    For licensing inquiries, please contact partnerships@abcam.com

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