Anti-Serine Palmitoyltransferase抗体(ab23696)
Key features and details
- Rabbit polyclonal to Serine Palmitoyltransferase
- Suitable for: WB
- Reacts with: Mouse, Rat, Human
- Isotype: IgG
概述
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产品名称
Anti-Serine Palmitoyltransferase抗体
参阅全部 Serine Palmitoyltransferase 一抗 -
描述
兔多克隆抗体to Serine Palmitoyltransferase -
宿主
Rabbit -
特异性
This antibody detects human serine palmitoyltransferase subunit SPT2 -
经测试应用
适用于: WBmore details -
种属反应性
与反应: Mouse, Rat, Human -
免疫原
Synthetic peptide:
LDRPFDETTYEETED
, corresponding to amino acids 548-562 of Human Serine Palmitoyltransferase. -
常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
存储溶液
pH: 7.20
Preservative: 0.02% Sodium azide
Constituents: 50% Glycerol (glycerin, glycerine), 49% PBS -
Concentration information loading...
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纯度
Immunogen affinity purified -
纯化说明
This antibody was affinity purifed. -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
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Recombinant Protein
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab23696于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
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WB | (2) |
Use a concentration of 1 µg/ml. Predicted molecular weight: 62 kDa.
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说明 |
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WB
Use a concentration of 1 µg/ml. Predicted molecular weight: 62 kDa. |
靶标
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功能
Serine palmitoyltransferase (SPT). The heterodimer formed with LCB1/SPTLC1 constitutes the catalytic core. The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference. The SPTLC1-SPTLC2-SSSPTA complex shows a strong preference for C16-CoA substrate, while the SPTLC1-SPTLC2-SSSPTB complex displays a preference for C18-CoA substrate. -
组织特异性
Widely expressed. -
通路
Lipid metabolism; sphingolipid metabolism. -
疾病相关
Defects in SPTLC2 are the cause of hereditary sensory and autonomic neuropathy type 1C (HSAN1C) [MIM:613640]. It is a form of hereditary sensory and autonomic neuropathy, a genetically and clinically heterogeneous group of disorders characterized by degeneration of dorsal root and autonomic ganglion cells, and by prominent sensory abnormalities with a variable degree of motor and autonomic dysfunction. The neurological phenotype is often complicated by severe infections, osteomyelitis, and amputations. HSAN1C symptoms include loss of touch and vibration in the feet, dysesthesia and severe panmodal sensory loss in the upper and lower limbs, distal lower limb sensory loss with ulceration and osteomyelitis, and distal muscle weakness. -
序列相似性
Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. -
细胞定位
Endoplasmic reticulum membrane. - Information by UniProt
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数据库链接
- Entrez Gene: 9517 Human
- Entrez Gene: 20773 Mouse
- Entrez Gene: 366697 Rat
- Omim: 605713 Human
- SwissProt: O15270 Human
- SwissProt: P97363 Mouse
- Unigene: 435661 Human
- Unigene: 565 Mouse
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别名
- KIAA0526 antibody
- LCB 2 antibody
- LCB2 antibody
see all
图片
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All lanes : Anti-Serine Palmitoyltransferase antibody (ab23696) at 1 µg/ml
Lane 1 : 30ug mouse brain homogenate.
Lane 2 : 30ug rat kidney supernatant.
Lane 3 : 30ug human liver microsome.
Predicted band size: 62 kDa
Observed band size: 67 kDa why is the actual band size different from the predicted?
数据表及文件
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SDS download
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Datasheet download
文献 (25)
ab23696 被引用在 25 文献中.
- Takeda S et al. Comparative Study on Epidermal Moisturizing Effects and Hydration Mechanisms of Rice-Derived Glucosylceramides and Ceramides. Int J Mol Sci 24:N/A (2022). PubMed: 36613524
- Hwang S et al. Consequences of aneuploidy in human fibroblasts with trisomy 21. Proc Natl Acad Sci U S A 118:N/A (2021). PubMed: 33526671
- Takeda S et al. ß-Sitosterol 3-O-D-glucoside increases ceramide levels in the stratum corneum via the up-regulated expression of ceramide synthase-3 and glucosylceramide synthase in a reconstructed human epidermal keratinization model. PLoS One 16:e0248150 (2021). PubMed: 33684145
- Zhou Q et al. Effect of Gegen Qinlian Decoction on Hepatic Gluconeogenesis in ZDF Rats with Type 2 Diabetes Mellitus Based on the Farnesol X Receptor/Ceramide Signaling Pathway Regulating Mitochondrial Metabolism and Endoplasmic Reticulum Stress. Evid Based Complement Alternat Med 2021:9922292 (2021). PubMed: 34422083
- Bugajev V et al. Crosstalk between ORMDL3, serine palmitoyltransferase, and 5-lipoxygenase in the sphingolipid and eicosanoid metabolic pathways. J Lipid Res 62:100121 (2021). PubMed: 34560079