Anti-SCAMP5抗体(ab3432)
Key features and details
- Rabbit polyclonal to SCAMP5
- Suitable for: WB
- Reacts with: Rat
- Isotype: IgG
概述
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产品名称
Anti-SCAMP5抗体
参阅全部 SCAMP5 一抗 -
描述
兔多克隆抗体to SCAMP5 -
宿主
Rabbit -
经测试应用
适用于: WBmore details -
种属反应性
与反应: Rat
预测可用于: Mouse, Human
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免疫原
Synthetic peptide corresponding to Rat SCAMP5 aa 217-233.
Sequence:NQPQTQYSATPNYTYSN
(Peptide available asab4971) -
常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
存储溶液
Preservative: 0.05% Sodium azide
Constituents: 0.1% BSA, 99% PBS -
Concentration information loading... -
纯度
Immunogen affinity purified -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
应用
| 应用 | Ab评论 | 说明 |
|---|---|---|
| WB | (2) |
Use a concentration of 2 µg/ml. Detects a band of approximately 25 kDa.
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| 说明 |
|---|
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WB
Use a concentration of 2 µg/ml. Detects a band of approximately 25 kDa. |
靶标
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功能
Required for the calcium-dependent exocytosis of signal sequence-containing cytokines such as CCL5. Probably acts in cooperation with the SNARE machinery. May play a role in accumulation of expanded polyglutamine (polyQ) protein huntingtin (HTT) in case of endoplasmic reticulum stress by inhibiting the endocytosis pathway. -
组织特异性
Expressed both by neuronal and nonneuronal tissues. Expressed in brain, stomach, thyroid, spinal cord, lymph node, trachea, adrenal gland, bone marrow and in the different parts of brain. In thyroid tissues, it is expressed by the follicular epithelial cells. In the adrenal gland tissues it is detected in the zona fasciculate of the cortex region (at protein level). -
序列相似性
Belongs to the SCAMP family. SCAMP5 subfamily. -
细胞定位
Cell membrane. Golgi apparatus membrane. Golgi apparatus > trans-Golgi network membrane. Recycling endosome membrane. Cytoplasmic vesicle > secretory vesicle > synaptic vesicle membrane. Mainly localizes in Golgi apparatus membrane. Upon calcium-triggered exocytosis, it translocates to the cell membrane. Highly enriched in synaptic vesicles. - Information by UniProt
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数据库链接
- Entrez Gene: 192683 Human
- Entrez Gene: 56807 Mouse
- Entrez Gene: 65171 Rat
- Omim: 613766 Human
- SwissProt: Q8TAC9 Human
- SwissProt: Q9JKD3 Mouse
- SwissProt: Q9JKE3 Rat
- Unigene: 374180 Human
see all -
别名
- AI426171 antibody
- AW558254 antibody
- DKFZp686L1799 antibody
see all
图片
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Western blot - Anti-SCAMP5 antibody (ab3432)Anti-SCAMP5 antibody (ab3432) + Rat brain extract
Observed band size: 25 kDa why is the actual band size different from the predicted?
实验方案
数据表及文件
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Datasheet download
文献 (2)
ab3432 被引用在 2 文献中.
- Yang Y et al. Secretory carrier membrane protein 5 is an autophagy inhibitor that promotes the secretion of a-synuclein via exosome. PLoS One 12:e0180892 (2017). WB ; Rat, Human . PubMed: 28700687
- Noh JY et al. SCAMP5 Links Endoplasmic Reticulum Stress to the Accumulation of Expanded Polyglutamine Protein Aggregates via Endocytosis Inhibition. J Biol Chem 284:11318-25 (2009). ICC/IF . PubMed: 19240033
