SB431542,ALK抑制剂(ab120163)
Key features and details
- ALK inhibitor
- CAS Number: 301836-41-9
- Soluble in DMSO to 100 mM and in ethanol to 10 mM
- Form / State: Solid
- Source: Synthetic
概述
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产品名称
SB431542,ALK抑制剂 -
描述
ALK抑制剂 -
生物学描述
Potent and selective inhibitor of Activin Like Kinase. Inhibits ALK 4, 5 (IC50 = 94 nM), and 7. 3D Growth matrix component; also component of brain and blood vessel organoid differentiation media.
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CAS编号
301836-41-9 -
化学结构
性能
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化学名称
4-[4-(3,4-Methylenedioxyphenyl)-5-(2-pyridyl)-1H-imidazol-2-yl]benzamide -
分子量
384.39 -
分子式
C22H16N4O3 -
PubChem识别号
4521392 -
存放说明
Store at Room Temperature. Store under desiccating conditions. The product can be stored for up to 12 months. -
溶解度概述
Soluble in DMSO to 100 mM and in ethanol to 10 mM -
处理
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
NC(=O)c1ccc(cc1)c3nc(c2ccccn2)c(n3)c4ccc5OCOc5c4 -
来源
Synthetic
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研究领域
实验方案
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
文献 (39)
ab120163 被引用在 39 文献中.
- Brazane M et al. The ribose methylation enzyme FTSJ1 has a conserved role in neuron morphology and learning performance. Life Sci Alliance 6:N/A (2023). PubMed: 36720500
- Li Z et al. Transcriptomics of Hirschsprung disease patient-derived enteric neural crest cells reveals a role for oxidative phosphorylation. Nat Commun 14:2157 (2023). PubMed: 37061531
- Deng S et al. Recruitment of regulatory T cells with rCCL17 promotes M2 microglia/macrophage polarization through TGFβ/TGFβR/Smad2/3 pathway in a mouse model of intracerebral hemorrhage. Exp Neurol 367:114451 (2023). PubMed: 37257716
- Shabani K et al. The temporal balance between self-renewal and differentiation of human neural stem cells requires the amyloid precursor protein. Sci Adv 9:eadd5002 (2023). PubMed: 37327344
- Riesenberg S et al. Efficient high-precision homology-directed repair-dependent genome editing by HDRobust. Nat Methods 20:1388-1399 (2023). PubMed: 37474806